Hemophilia Timeline 

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1803 – Dr. John Conrad Otto recognized a bleeding condition was hereditary and affected males. He traced it back to a woman who settled near Plymouth, New Hampshire in 1720.

1828 – The word “Hemophilia” is first used to describe a bleeding disorder condition at the University of Zurich.

1837 – Queen Victoria of England was a carrier of the hemophilia gene, which was passed to several royal families. (although there is nothing "royal" about Hemophilia)

1925 – von Willebrand disease was first recognized by Finnish physician Erik von Willebrand.

1937 – Doctors learned clotting problems could be corrected by adding platelet-free plasma, which was called “anti-hemophilic globulin.”

1944 – Recognition of hemophilia A and hemophilia B as two distinct diseases by Dr. Pavlosky came after he identified two patients each deficient in different proteins.

1950s – 1960s – Whole blood or fresh plasma were used to treat hemophilia and other bleeding problems. These treatments lacked enough factor VIII or IX proteins to stop serious bleeds.

1965 – Dr. Judith Graham Pool found that cryoprecipitate contained a significant amount of factor that could be used to control severe bleeding. The need for high-volume whole plasma transfusions for people with hemophilia was eliminated.

1970 – Freeze-dried powdered concentrates containing factor VIII and IX became available by the 1970s

1980s – HIV/AIDS could be transmitted through the use of blood and blood products. About half of the U.S. population with hemophilia became HIV-infected and thousands would die.

1992 – The first recombinant factor VIII product was approved by the FDA.

1997 – The first factor IX product was granted FDA Approval.

1990s – Prophylactic (a preventative treatment plan) in children with hemophilia became more common in the mid-1990s.

2014 - Extended half-life was approved by the FDA.

2018 - emicizumab (Hemlibra) was approved by the FDA allowing Hemophilia patients to administer subcutaneously once a month. 

Disclaimer: Nothing on Fixx Pharmaceuticals should be construed as medical advice or replace medical advice, medical visits, or recommendations from a health care professional. Patients should always consult with a doctor or other health care professional for medical advice. 

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